Synthesis, Structure and Antiradical Activity of Functionally Substituted Hydrazides of Isonicotinic Acid

The purpose of this work is the synthesis new isonicotinic acid hydrazones, study their structure, reactivity and biological screening some synthesized compounds. reactions leading to N-arylidene(alkylidene) hydrazones via condensation hydrazide with various derivatives aromatic aldehydes were studied. structure functionally substituted was established by FTIR, 1H 13C NMR, two-dimensional COSY (1H-1H) NMR spectroscopy HMQC (1H-13C). antiradical activity studied using diphenylpycrylhydrazide radical (DPPH) assay. It shown that N-(3- ethoxy-4-hydroxybenzylidene)isonicotinohydrazide possesses (IC50 103.0 μM). properties compounds phenolic nature are in agreement energies homolytic O-H bond dissociation calculated use density functional theory.